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iPSC-derived liver organoids contain a resident macrophage and hepatic stellate cell population scRNAseq data identified a discrete population of Kupffer cells, which are the resident macrophage population of the liver and are derived in situ during the hematopoietic phase of liver development in vivo 59,60

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A 2016 comparative study published in Nature Scientific Reports directly compared copper compounds and found GHK-Cu non-cytotoxic across all tested concentrations up to 5,800 micromolar over 72 hours